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Actinomycetes are widely distributed in nature, in particular on plants, they can enter the body with plants and be on the mucous membranes as a saprophyte. The transition of actinomycetes from a saprophytic to a parasitic state is facilitated by inflammatory diseases of the mucous membranes of the oral cavity, respiratory and gastrointestinal tract. At the site of the introduction of cenforce, an infectious granuloma is formed, which grows into the surrounding tissues. Abscesses appear in the granulations, which, breaking through, form fistulas. Skin lesions are secondary.

In the formation of suppuration, a secondary, mainly staphylococcal infection also plays a role. Antigens of radiant fungi lead to specific sensitization and allergic restructuring of the body (hypersensitization of the delayed or cenforce type), as well as to the formation of antibodies (complement binding, agglutinins, precipitins, etc.).